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Download Actin-based Motility: Cellular, Molecular and Physical by J. Victor Small, Klemens Rottner (auth.), Marie-France PDF

By J. Victor Small, Klemens Rottner (auth.), Marie-France Carlier (eds.)

This ebook provides the mobile, molecular and actual features of strength and stream by means of the self-assembly of actin, the most plentiful proteins present in cells, into cytoskeletal filaments. « Actin-based motile strategies » are answerable for a wide number of motile actions akin to chemotactic locomotion, embryonic and metastatic mobile migration, wound therapeutic, eukaryotic cytokinesis and bacterial plasmid segregation, endocytic and phagocytic actions, in addition to morphogenetic approaches together with, axis patterning in early embryos, axonal progress in mind improvement, and the immune reaction and synaptic plasticity methods on the foundation of studying and reminiscence. The booklet describes how the lately undertaken multidisciplinary and multiscale techniques have explored the molecular and actual mechanisms on the starting place of strength and move produced via actin self-assembly. the selected subject matters express how advances were made within the box of mobilephone motility as a result development in dwell mobilephone imaging, mild microscopy, more desirable answer within the constitution of huge protein assemblies, the biochemical research and mathematical modeling of actin meeting dynamics and the advance of nanotechnologies allowing us to degree forces within the variety of pico- to nano-newtons produced through actin assemblies.

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Additional resources for Actin-based Motility: Cellular, Molecular and Physical Aspects

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Le Clainche, and D. Pantaloni. 2003. Actin-based motility as a selforganized system: mechanism and reconstitution in vitro. C R Biol. 326:161–70. , and E. Paluch. 2008. Blebs lead the way: How to migrate without lamellipodia. Nat Rev Mol Cell Biol. 9:730–36. L. Goode. 2009. Actin nucleation and elongation factors: mechanisms and interplay. Curr Opin Cell Biol. 21:28–37. E. A. E. Holt. 1993. Navigational errors made by growth cones without filopodia in the embryonic Xenopus brain. Neuron. 11:237–51.

S. Alberts, S. B. Gertler. 2007. Filopodia are required for cortical neurite initiation. Nat Cell Biol. 9:1347–59. S. Izzard. 1987. Evidence for an actin-containing cytoplasmic precursor of the focal contact and the timing of incorporation of vinculin at the focal contact. J Cell Biol. 105:2803–9. , J. Fink, D. Martin, A. Houdusse, M. E. Stradal, D. Louvard, and A. Gautreau. 2008. Free Brick1 is a trimeric precursor in the assembly of a functional wave complex. PLoS One. 3:e2462. B. 2009. Models for actin polymerization motors.

Proc Natl Acad Sci U S A. 103:7694–99. , T. Bretschneider, R. Arasada, M. Schleicher, and J. Faix. 2005. The Diaphanousrelated formin dDia2 is required for the formation and maintenance of filopodia. Nat Cell Biol. 7:619–25. , and J. Wehland. 2004. ENA/VASP proteins: multifunctional regulators of actin cytoskeleton dynamics. Front Biosci. 9:1294–310. V. 1981. Organization of actin in the leading edge of cultured cells: influence of osmium tetroxide and dehydration on the ultrastructure of actin meshworks.

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