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By P.G. LeFevre

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Z I:::I 0 u \ - -- \ -- PHOSPHOCREA TINE A- :z PLASMA INORGANIC PHOSPHATE ~ 30 - 6 5 4 2 / / / / / / / /'" r-- \. / '\ '\ \ INTRACELLULAR INORGANIC PHOSPHATE 8 16 TIME AFTER INJECTION, HOURS Fig. 16. Time course of P" uptake by phosphocreatine and intracellular inorganic P of heart muscle of cats. /mg. P are adjusted to standard initial injection 5 . 10' counts/min. per kg. of body weight. (Courtesy of J. SACKS and Cold Spring Harbor Symposia) largely on the basis simply of the known physical and chemical make-up of the erythrocyte surface and consideration of the possible interplay of the ingredients by reason of their general chemical properties.

According to WHITTAM and DAVIES (1953 b), the K42 exchange aerobically has a higher temperature coefficient than does the anaerobic transfer. The somewhat faster Na 2 ! turnover also shows two or more compartments for the cellular Na (WHITTAM and DAVIES 1954). 2 experiments, WHITTAM and DAVIES (1953 b) calculated that only a fraction of the Na+ distribution could be by simple passive means. ~R (1941), horse leucocytes behave just like yeast cells with regard to the effect of glucose Oil the movements of K+.

Courtesy of R. F. PITTS and American Journal of Physiology) apparently not very high, since, as the figure shows, maximal reabsorption requires a plasma phosphate level significantly higher than the threshold concentration 21. The significance of phlorrhizination to the phosphate reabsorption system has been a matter of some debate. ALLAN, DICKSON, and MARKOWITZ (1924) reported that in dogs phlorrhizin might canse a doubling of the urinary loss of phosphorus (following a transient slight drop).

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