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Additional info for Adrenal Glands: Diagnostic Aspects and Surgical Therapy
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1 HPA Axis: Immune System . . 2 HPA Axis: Other Endocrine Axes . . 4 HPA Axis: Pathophysiology . . 26 References . . 1 Introduction The hypothalamic-pituitary-adrenal (HPA) axis outlines the tight hormonal coupling of the hypothalamus, the anterior pituitary and the adrenal cortex (Fig. 1). The HPA axis is a vital component of the stress system and mediates a variety of adaptive responses to stressors that threaten body homeostasis. Basal and stressrelated homeostasis depend on the integrity of the HPA axis, which additionally exerts profound regulatory effects on other systems (immune, endocrine and metabolic) in order to orchestrate a response that will allow endurance against any imposed challenge and preserve the internal milieu.